Amyotrophic lateral sclerosis (als), often referred to as "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord.
Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in als eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost.
A-myo-trophic comes from the Greek language. "A" means no or negative. "Myo" refers to muscle, and "Trophic" means nourishment–"No muscle nourishment." When a muscle has no nourishment, it "atrophies" or wastes away. "Lateral" identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening ("sclerosis") in the region.
As motor neurons degenerate, they can no longer send impulses to the muscle fibers that normally result in muscle movement.
Initially, the symptoms of als may be so subtle that the symptoms are not even noticed. Eventually, one experiences obvious weakness and/or muscle atrophy. This is followed by twitching, cramping, or stiffness of affected muscles, and/or slurred and nasal speech. The twitching, cramping, etc. associated with als is a result of the dying motor neurons.
With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Like virtually all neurodegenerative disorders, the cause of als is still undefined. However, one strong possibilty is the idea of a neurodegenerative chain-reaction which is common in all neurodegenerative disorders in which cellular 'faults' produce or induce some type of a ‘cascade’ failure that leads to progressive neuronal loss and progressive degeneration. Given that familial als has been linked to a mutation on the gene coding for superoxide dismutase (a critical enzyme involved in the protection of mitochondria against oxidative stress), early work has focused on oxidative stress again, a probable mechanism in virtually all neurodegenerative disorders.
Oxidative stress is created (and managed) within the mitochondria, the primary chemical energy generation system in each cell. Most free radicals (which cause oxidative stress) are produced in the mitochondria but, there are extensive cellular defenses against this stress in the mitochondria itself (in which superoxide dismutase plays an important but not exclusive role).
A critical issue is the emerging evidence that in aging, there is probably progressive damage to mitochondrial DNA and progressive failure of the mechanisms by which the mitochondria are protected from oxidative stress. There is work suggesting that progressive damage to the mitochondria is a central mechanism in age-related change in general so, damage to the mitochondria may be a common denominator in all age-related neurodegenerative diseases.
Failure of the mitochondria to manage oxidative stress can lead to a lot of undesirable effects, including premature cell death, damage to other cellular organelles and disorders of protein folding (an area of increasing interest in als and many other neurodegenerative disorders).
Since neurons, with a few exceptions, cannot be replaced, any process that stimulates premature cell death of motor neurons will eventually lead to negative motor symptoms and eventual motor system failure. Evidence suggests that premature cell death may be stimulated (as a primary cause of atrophy) in both upper and lower motor neuron groups in als.
The onset of als has been linked to several factors, including: a virus; exposure to various neurotoxins or heavy metals; DNA defects; immune system abnormalities; occupational involvement in military service and elite sports (where the issue again may be toxic exposure); and enzyme abnormalities.
Surgeries involving the spinal cord have also been thought to play a role in the onset of als, possibly due to the increased burden of oxidative stress and inflammation after spinal cord injury or stress.
There is a known hereditary factor in familial als (Fals); however, there is no known hereditary component in the 90–95% cases diagnosed as sporadic als. An inherited genetic defect on chromosome 21 (coding for superoxide dismutase) is associated with approximately 20% of familial cases of als. The children of those diagnosed with familial als have a higher risk factor for developing the disease; however, those who have close family members diagnosed with sporadic als have no greater a risk factor than the general population, suggesting again an environmental or other non-genetic cause.
Some environmental causative factors have been suggested for the increased incidence in the western Pacific. Prolonged exposure to a dietary neurotoxin called BMAA is one suspected risk factor in Guam; the neurotoxin is a compound found in the seed of the cycad Cycas circinalis, a tropical plant found in Guam, which was used in the human food supply during the 1950s and early 1960s.
The very high incidence of the disease among Italian soccer players (more than five times higher than normally expected) shows a possible link between the disease and the use of pesticides on the soccer fields (several of which have been linked to neuronal toxicity).
According to the als Association, military veterans are at an increased risk of contracting als (again, possibly implying a link to neurotoxic chemical exposure). In its report als in the Military, the group pointed to an almost 60% greater chance of the disease in military veterans than the general population.
The former Indian Army Chief of Staff General K.Sunderji also suffered from als before passing away. For Gulf War veterans, the chance is seen as twice that of veterans not deployed to the Persian Gulf in a joint study by the Veterans Affairs Administration and the DOD, another epidemiologic association suggesting a link to toxic exposure.
Dietary intake of polyunsaturated fatty acids (PUFA) has been shown in several studies to decrease the risk of developing als and other neurodegenerative disorders, probably through several mechanisms, including promotion of neurotrophins such as BDNF
1. Conwit, Robin A. (December 2006). "Preventing familial als: A clinical trial may be feasible but is an efficacy trial warranted?". Journal of the Neurological Sciences 251 (1–2)
2. Al-Chalabi, Ammar; P. Nigel Leigh (August 2000). "Recent advances in amyotrophic lateral sclerosis". Current Opinion in Neurology 13 (4): 397–405. ISSN 1473-6551 PMID 10970056
4. Khabazian I, Bains JS, Williams DE, Cheung J, Wilson JM, Pasqualotto BA, Pelech SL, Andersen RJ, Wang YT, Liu L, Nagai A, Kim SU, Craig UK, Shaw CA (August 2002). Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for als-parkinsonism dementia J. Neurochem.
5. Sla, indagini nei club. Pesticidi nel mirino" Retrieved 2008-10-02.
6. Sla, una strage nel calcio" Retrieved 2008-10-02.
7. als in the Military The als Association. 2007-05-17. Retrieved 2008-05-01.
Use them at least six months or longer. More could be done, supplements that would be important or very good to add on, but these are the best.
I’m putting them in order of importance, starting with the most valuable ones.
Detoxification is a big issue with his ALS. Too many toxins in cells, the liver not handling toxins well. The first two supplements focus on this.
2 bottles a month Glutathione Force II
This is a liposomal glutathione supplement that delivers into your cells the very hard to absorb glutathione molecule. It is the #1 nutrient for detoxing cells and the #2 cellular antioxidant. Glutathione Force focuses on removing excess toxicity, improving cellular health, and on increasing the production of energy in cells. Not only does it get glutathione into cells to help detoxify them, but it also carries in CoQ10, R-Alpha Lipoic Acid, D Ribose, and many other nutrients that improve cellular health, along with the health of your heart and liver. It both helps to detoxify cells and renew cell function.
This herbal formula builds upon the established antioxidant combination of alpha-lipoic acid, silymarin and selenium originally developed by Burt Berkson M.D. for the highly successful treatment of acute liver degeneration. It brings together therapeutic levels of these three much researched liver protective nutrients in their most effective and absorbable forms -- and adds on five other liver protective antioxidants including a patented CoQ10 from Germany.
In addition to antioxidants, UltraLiver12 provides cell membrane stabilizing agents, bile secretion enhancing compounds and nutrients that prevent depletion of endogenous antioxidants such as glutathione.
2 bottles a month Super PEO Essential Fatty Acid Formula
This 8 ounce bottle is a combination of organic cold pressed oils and essential oils that supplies the optimal ratio of Omega 3’s and Omega 6’s for cell health and cardiovascular health. This optimal ratio made from high quality oils enables the body to build high quality, permeable cell walls. This enables cells to uptake oxygen and nutrients much more efficiently. Research has shown that poor quality polyunsaturated fatty acids clog up cell wall function and contribute to inflammation in the body. Your body will use the high quality fatty acids found in Super PEO in preference to other poor quality oils in the diet.
2 bottles a month Super ProCoQ10-Max
This is a highly absorbable ester fat soluable CoQ10 with niacin and lithium to boost cell performance. CoQ10 is necessary in order for cells to efficiently produce energy using oxygen. Low levels of CoQ10 lead to poor cell functioning. Use this in addition to what is already in the Glutathione Force II and UltraLiver12.
This is a combination of organic vegetable protein, ingredients to increase nitric oxide production and thus circulation, and nutrients to support cellular health. CellPro is designed to support healing and repair, and needs to be used in ALS in especially high doses.
I’ve had several people, including adults with many many symptoms, that had amazing results using ESME version A because it improves cellular health so much. The minerals in it and the structured energized water work to energize cells and help them repair. Just what you need with ALS.
This frequency enhanced elixir optimizes production of high quality cholesterol by the liver, increasing production in the rare cases where cholesterol levels are low, and decreasing production of cholesterol when levels are high — in all cases turning on production of high quality cholesterol. In addition the lymph system is instructed to pull excess cholesterol out of the blood, sending it out of the body through the skin. Poor quality or damaged and oxidized cholesterol are prioritized for removal. In Howard’s case, With ALS you usually need more high quality cholesterol as this is a major building block of cell walls and not enough is getting into cells.
This elixir is a unique and powerful way to deal with candida fungal overgrowth and all other pathogens in the body. It tells the immune system to grab hold of candida and escort it out of the body without killing it. Reducing die off symptoms. Does the same for bad bacteria, mycoplasma and viruses too. It also tells the immune system to grab candida spores and carry them out. In addition the lymph system is alerted to package up candida, fungal spores, and pathogens of all types, and to carry them to the skin or colon wall, to push them through and eliminate them from the body.
This elixir turns on production of the STAT 1 protein which stops viral replication. It has energies that drive viruses out of cells so that they can be exposed to the immune system and other anti-viral supplements. It also is activates an immune system response not only to kill viruses, but to grab hold of them and carry them out of the body. These actions are designed to enable even chronic viral infections like the herpes viruses that hide in nerve cells to be gradually eliminated over the course of six months.
This elixir now activates production of nano oxygen in the body that will both support any areas of the body suffering from low oxygenation, such as the brain after a stroke, or with neuropathy. Powerfully fights cancer, candida and infections. It tells the body to optimize all aspects of getting more oxygen into cells. In addition it increases cellular hydration and cellular energy production by optimizing all aspects influencing the uptake of water into cells. Low cellular hydration is related to poor health and illness and high cellular hydration corresponds with excellent health. Oxy Life Force Elixir works best when used with equal amounts of OxyDHQ.
This liquid concentrate creates oxygen in the body by supplying extra deuterium, found naturally in the body, in an acid base. This process helps to create oxyten in cells, where you need to have it. Stimulates repair, healing, energy and detoxing.
Again, lack of the proper fats getting into cells contributes to the development of ALS. This elixir optimizes fatty acid transport protein levels. This elixir increases these levels and optimizes all aspects of fatty acid utilization and absorption into cells. It seems that toxins must have disrupted production of these in your husband’s case, so that the cells can’t uptake and utilize fats. This is likely a major contributor to the development of ALS.
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