Dealing With Undifferentiated Connective Tissue Disease

Undifferentiated Connective Tissue Disease is found worldwide and affects all races of people although studies suggest that whites are most likely to be affected. People of all ages may develop UCTD although in mainly occurs in middle age and women are affected about ten times more

Symptoms of UCTD

The most common signs and symptoms of UCTD include arthritis, arthralgias (severe joint pain), Raynaud’s phenomenon, eye dryness (sicca syndrome), pleuritis/pericarditis (inflammation of the lining tissue around the heart or lungs), peripheral neuropathy, vasculitis, fever, weight loss, fatigue, mucocutaneous manifestations, cutaneous (skin) involvement including malar rash, hives, skin tightening and alopecia (hair loss), respiratory symptoms, urethral discharge, muscle weakness, myositis, rash, and leukopenia (low white blood cell count) but with no neurological symptoms or kidney problems.

About 80 percent of patients with UCTD have only one auto antibody, usually anti-Ro or anti-RNP.

In some cases, patients who are initially diagnosed with Raynaud’s phenomenon alone go on to develop undifferentiated connective tissue disease.

Many people diagnosed with undifferentiated connective disease have a specific autoimmune disorder such as SLE within the first year from diagnosis. This is where the body is sending out the immune system to attack the connective tissue. Usually, there is a pathogen responsible for the initial attack which can not be reached with traditional treatments. The immune system gets imbalanced in it's continued attempts to get to the pathogen in the connective tissues and the symptoms arise.

In one five-year study of patients newly diagnosed with SLE, most whose UCTD differentiated into a specific disorder developed Sjogren’s syndrome, followed by SLE, mixed connective tissue disease, systemic vasculitis, progressive systemic sclerosis, and poymyositis/dermatomyositis. Overall, most patients with UCTD who develop a specific connective tissue disease do so within the first two years following the initial diagnosis.

However, in this and other studies, about 10 percent of newly diagnosed patients experience complete remission within one year. Within the first five years following diagnosis, about 65 percent of patients experience a reduction in symptoms, develop new symptoms, or continue to manifest the same signs and symptoms of UCTD indefinitely.


UCTD is diagnosed in people with symptoms of an autoimmune condition or, connective tissue disease who do not seem to have any other known disorders.


Treatments for UCTD vary and depend on the type and the severity of the symptoms and how long the person has been ill. Common treatments include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressive agents, calcium channel blockers, and cyclooxygenase-2 inhibitors.

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1-800-832-9755 in the USA or

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Good Luck And Good Health!